Director of Studies: Dr Shakil Awan
Co-Supervisors:
Professor Des Mapps (des.mapps@plymouth.ac.uk, +44 1752 600600)
Dr Martin Peacock, Zimmer & Peacock Ltd
Applications are invited for a 3.5-year PhD studentship. The studentship will start on 1 January 2022.
Project description
This studentship is for a graduate to join our multi-disciplinary research group investigating a new safe treatment for cancer of the brain. The graduate will enrol for a higher degree aimed at achieving a PhD within three years. The treatment involves the use of low-intensity Electric Fields which are known to prevent the uncontrolled division of cancer cells. This treatment, if optimised, could revolutionise the treatment of fatal brain tumours such as Glioblastomas. It may also extend to other types of cancers. Currently, a treatment is already approved in the USA (see https://www.optune.com/) and used together with chemotherapy drugs to slow down the progress of the cancer. The aim of this project is to maximise the efficacy of the Electric Fields so as to render the chemotherapy drugs unnecessary.
To achieve optimization of the electric fields we are currently exploring the effect on cells inside the eggs of the common fruit fly (Drosophila). These cells divide much faster than human cancer cells so allowing direct observation of the dividing process under a high-resolution microscope.
The project is in collaboration between the School of Engineering, Computing and Mathematics (SECaM), Peninsula School of Medicine and our industrial partner Zimmer & Peacock Ltd. The project will involve design and development of electronics, electric field electrode systems and graphene sensors. You will also gain experience of behavioural assays, immunohistochemistry, expression of fluorescent proteins and confocal microscopy.
Eligibility
Applicants should have (at least) a first or upper second class honours degree in an appropriate subject and preferably a relevant MSc or MRes qualification. Some background and expertise in Biochemistry, Bioelectronics and Biosensors as well as practical experience of conducting experiments and data analysis is desirable.
The studentship is supported for 3.5 years and includes full Home tuition fees plus a stipend of £15,609 per annum (2021/22 rate). The studentship will only fully fund those applicants who are eligible for Home fees with relevant qualifications. Applicants required to cover International fees will normally have to cover the difference between the Home and the International tuition fee rates (approximately £12,697 per annum).
If you wish to discuss this project further informally, please contact Dr Shakil Awan.
Please refer to the list of supporting documents to upload with your application.
For more information on the admissions process generally, please contact doctoralcollege@plymouth.ac.uk.
The closing date for applications is 12 noon on 1 October 2021.
Shortlisted candidates will be invited for interview by 11 October 2021. We regret that we may not be able to respond to all applications. Applicants who have not received an offer of a place by 18 October 2021 should consider their application has been unsuccessful on this occasion.